Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts

The aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the n-BuOH extract of Centaurea maroccana (BECM). The total phenolic and flavonoid of the butanolic extract of the plant were assessed by using Folin-Ciocalteau and aluminium chl...

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Main Authors:	Aissous Imen, Benrebai Mouad, Cacan Ercan, Caglar Berkel, Erenler Ramazan, Ameddah Souad, Benayache Samir, Benayache Fadila, Bensouici Chawki
Format:	Article
Language:	English
Published:	Sciendo 2021-03-01
Series:	Current Issues in Pharmacy and Medical Sciences
Subjects:	centaurea maroccana phenolic contents antioxidant activity anti-proliferative activity
Online Access:	https://doi.org/10.2478/cipms-2021-0002

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record_format	Article
spelling	doaj-1080f6e373fe442482908cdaf0a0ec202021-09-06T19:22:05ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2084-980X2300-66762021-03-0134151110.2478/cipms-2021-0002Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial partsAissous Imen0Benrebai Mouad1Cacan Ercan2Caglar Berkel3Erenler Ramazan4Ameddah Souad5Benayache Samir6Benayache Fadila7Bensouici Chawki8Laboratory of Biology and Environment, Faculty of Sciences of Nature and Life, University of Mentouri Constantine 1, Constantine, AlgeriaLaboratory of Biology and Environment, Faculty of Sciences of Nature and Life, University of Mentouri Constantine 1, Constantine, AlgeriaTokat Gaziosmanpasa University, Department of Molecular Biology and Genetics, Tokat, TurkeyTokat Gaziosmanpasa University, Department of Molecular Biology and Genetics, Tokat, TurkeyTokat Gaziosmanpasa University, Faculty of Arts and Sciences, Department of Chemistry, Tokat, TurkeyLaboratory of Biology and Environment, Faculty of Sciences of Nature and Life, University of Mentouri Constantine 1, Constantine, AlgeriaValorization of Natural Resources Unit, Bioactive Molecules and Physicochemical and Biological Analysis (VARENBIOMOL), University of Mentouri Constantine 1, Constantine, AlgeriaValorization of Natural Resources Unit, Bioactive Molecules and Physicochemical and Biological Analysis (VARENBIOMOL), University of Mentouri Constantine 1, Constantine, AlgeriaBiotechnology Research Center (CRBt), Ali Mendjli, Constantine, AlgeriaThe aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the n-BuOH extract of Centaurea maroccana (BECM). The total phenolic and flavonoid of the butanolic extract of the plant were assessed by using Folin-Ciocalteau and aluminium chloride colorimetric assays, respectively, and the quantitative estimation of total flavonoids and phenols revealed the richness of the extract in these compounds. Antioxidant activity was evaluated using standard lab colorimetric methods, while the anti-proliferative activity was evaluated using sulforhodamine B (SRB) assay against C6 (Rattus norvegicus brain glioma) and HT29 (Homo sapiens colorectal adenocarcinoma) cell lines. The n-butanolic extract of Centaurea maroccana showed a strong antioxidant activity through DPPH, ABTS•+, DMSO alkalin, Reducing power, β-Carotene-linoleic acid and CUPRAC assays. Furthermore, the anti-proliferative activity against C6 and HT29 of Centaurea maroccana exhibited a high effect by the decrease in viability of both cancer cell lines. Our results suggest a possible use of Centaurea maroccana as a source of natural antioxidant and chemo-preventive agents against cancer.https://doi.org/10.2478/cipms-2021-0002centaurea maroccanaphenolic contentsantioxidant activityanti-proliferative activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Aissous Imen Benrebai Mouad Cacan Ercan Caglar Berkel Erenler Ramazan Ameddah Souad Benayache Samir Benayache Fadila Bensouici Chawki
spellingShingle	Aissous Imen Benrebai Mouad Cacan Ercan Caglar Berkel Erenler Ramazan Ameddah Souad Benayache Samir Benayache Fadila Bensouici Chawki Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts Current Issues in Pharmacy and Medical Sciences centaurea maroccana phenolic contents antioxidant activity anti-proliferative activity
author_facet	Aissous Imen Benrebai Mouad Cacan Ercan Caglar Berkel Erenler Ramazan Ameddah Souad Benayache Samir Benayache Fadila Bensouici Chawki
author_sort	Aissous Imen
title	Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts
title_short	Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts
title_full	Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts
title_fullStr	Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts
title_full_unstemmed	Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts
title_sort	antioxidant and antiproliferative activities of the n-butanol extract of centaurea maroccana ball aerial parts
publisher	Sciendo
series	Current Issues in Pharmacy and Medical Sciences
issn	2084-980X 2300-6676
publishDate	2021-03-01
description	The aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the n-BuOH extract of Centaurea maroccana (BECM). The total phenolic and flavonoid of the butanolic extract of the plant were assessed by using Folin-Ciocalteau and aluminium chloride colorimetric assays, respectively, and the quantitative estimation of total flavonoids and phenols revealed the richness of the extract in these compounds. Antioxidant activity was evaluated using standard lab colorimetric methods, while the anti-proliferative activity was evaluated using sulforhodamine B (SRB) assay against C6 (Rattus norvegicus brain glioma) and HT29 (Homo sapiens colorectal adenocarcinoma) cell lines. The n-butanolic extract of Centaurea maroccana showed a strong antioxidant activity through DPPH, ABTS•+, DMSO alkalin, Reducing power, β-Carotene-linoleic acid and CUPRAC assays. Furthermore, the anti-proliferative activity against C6 and HT29 of Centaurea maroccana exhibited a high effect by the decrease in viability of both cancer cell lines. Our results suggest a possible use of Centaurea maroccana as a source of natural antioxidant and chemo-preventive agents against cancer.
topic	centaurea maroccana phenolic contents antioxidant activity anti-proliferative activity
url	https://doi.org/10.2478/cipms-2021-0002
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Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts

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