RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways

RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways

Background: Myocardial apoptosis is heavily implicated in the myocardial damage caused by ischemia-reperfusion (I/R). Toll-like receptor 4 (TLR4) is a potent inducer of these apoptotic cascades. In contrast, the radioprotective 105 kDa protein (RP105) is a specific negative regulator of TLR4 signali...

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Bibliographic Details
Main Authors: Jun Yang, Xin Guo, Jian Yang, Jia-wang Ding, Song Li, Rui Yang, Zhi-xing Fan, Chao-jun Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
TLR4
RP105
Ischemia/reperfusion injury
Myocardial apoptosis
Online Access:http://www.karger.com/Article/FullText/430180

Internet

http://www.karger.com/Article/FullText/430180

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