What can computational modeling offer for studying the Ca2+ dysregulation in Alzheimer’s disease: current research and future directions

What can computational modeling offer for studying the Ca2+ dysregulation in Alzheimer’s disease: current research and future directions

Ca2+ dysregulation is an early event observed in Alzheimer’s disease (AD) patients preceding the presence of its clinical symptoms. Dysregulation of neuronal Ca2+ will cause synaptic loss and neuronal death, eventually leading to memory impairments and cognitive decline. Treatments targeting Ca2+ si...

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Bibliographic Details
Main Authors: Jingyi Liang, Don Kulasiri
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
Alzheimer′s disease; amyloid-beta; Ca2+ hypothesis; Ca2+ dysregulation; computational modeling; computational neuroscience
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=7;spage=1156;epage=1158;aulast=Liang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=7;spage=1156;epage=1158;aulast=Liang

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