Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse. Sequencing the NS genome segment of mouse-adapted variants revealed 11 mutations in the NS1 gene and 4 in the overlapping NEP...

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Bibliographic Details
Main Authors: Nicole E Forbes, Jihui Ping, Samar K Dankar, Jian-Jun Jia, Mohammed Selman, Liya Keleta, Yan Zhou, Earl G Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3283688?pdf=render

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http://europepmc.org/articles/PMC3283688?pdf=render

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