Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue
Obesity: Possible protective enzyme identified An enzyme that limits the build-up of reactive oxygen species (ROS) in fat cells protects mice against metabolic stress during a high-fat diet. Calorie overload leads to high levels of damaging ROS in the mitochondria of brown fat cells. This can disrup...
Main Authors: | Jae-Ho Lee, Younghoon Go, Do-Young Kim, Sun Hee Lee, Ok-Hee Kim, Yong Hyun Jeon, Taeg Kyu Kwon, Jae-Hoon Bae, Dae-Kyu Song, Im Joo Rhyu, In-Kyu Lee, Minho Shong, Byung-Chul Oh, Christopher Petucci, Jeen-Woo Park, Timothy F. Osborne, Seung-Soon Im |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-02-01
|
Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-020-0379-z |
Similar Items
-
Correction: Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue
by: Jae-Ho Lee, et al.
Published: (2020-06-01) -
Isocitrate dehydrogenase
by: Illingworth, J. A.
Published: (1970) -
DPN-linked isocitrate dehydrogenase from fly thoracic muscle mitochondria
by: Gu, Deye
Published: (2019) -
The radiation inactivation of glutamate and isocitrate dehydrogenases
by: Abu El Failat, R. R.
Published: (1980) -
Studies on NADP-linked isocitrate dehydrogenase
by: Londesborough, J.
Published: (1969)