Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

It is traditionally believed that callosal and non-callosal fates are determined early after a neuron’s birth, and that cortical layer (L) 4 excitatory neurons of the primary somatosensory (S1) barrel cortex project only ipsilaterally. However, here authors demonstrate, using a novel axonal retrotra...

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Main Authors: N. S. De León Reyes, S. Mederos, I. Varela, L. A. Weiss, G. Perea, M. J. Galazo, M. Nieto
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12495-w
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spelling doaj-106cb058e4634e248a4c78643c8fc11a2021-05-11T12:37:34ZengNature Publishing GroupNature Communications2041-17232019-10-0110111510.1038/s41467-019-12495-wTransient callosal projections of L4 neurons are eliminated for the acquisition of local connectivityN. S. De León Reyes0S. Mederos1I. Varela2L. A. Weiss3G. Perea4M. J. Galazo5M. Nieto6Department of Cellular and Molecular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC)Instituto Cajal, CSIC. Av. Doctor Arce, 37Department of Cellular and Molecular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC)Department of Cellular and Molecular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC)Instituto Cajal, CSIC. Av. Doctor Arce, 37Department of Cell and Molecular Biology and Tulane Brain Institute, Tulane UniversityDepartment of Cellular and Molecular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC)It is traditionally believed that callosal and non-callosal fates are determined early after a neuron’s birth, and that cortical layer (L) 4 excitatory neurons of the primary somatosensory (S1) barrel cortex project only ipsilaterally. However, here authors demonstrate, using a novel axonal retrotracing strategy, that L4 neurons develop transient interhemispheric axons that are refined in an area- and layer-specific manner during postnatal development.https://doi.org/10.1038/s41467-019-12495-w
collection DOAJ
language English
format Article
sources DOAJ
author N. S. De León Reyes
S. Mederos
I. Varela
L. A. Weiss
G. Perea
M. J. Galazo
M. Nieto
spellingShingle N. S. De León Reyes
S. Mederos
I. Varela
L. A. Weiss
G. Perea
M. J. Galazo
M. Nieto
Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
Nature Communications
author_facet N. S. De León Reyes
S. Mederos
I. Varela
L. A. Weiss
G. Perea
M. J. Galazo
M. Nieto
author_sort N. S. De León Reyes
title Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_short Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_full Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_fullStr Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_full_unstemmed Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_sort transient callosal projections of l4 neurons are eliminated for the acquisition of local connectivity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description It is traditionally believed that callosal and non-callosal fates are determined early after a neuron’s birth, and that cortical layer (L) 4 excitatory neurons of the primary somatosensory (S1) barrel cortex project only ipsilaterally. However, here authors demonstrate, using a novel axonal retrotracing strategy, that L4 neurons develop transient interhemispheric axons that are refined in an area- and layer-specific manner during postnatal development.
url https://doi.org/10.1038/s41467-019-12495-w
work_keys_str_mv AT nsdeleonreyes transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
AT smederos transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
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AT laweiss transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
AT gperea transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
AT mjgalazo transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
AT mnieto transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
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