Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study

Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study

Proteomic technologies have been recently adapted to the new field of clinical proteomics. The origin of errors and biases has been well-identified in the pre-analytical steps, leading to the measurement of clinical analytes. One possible source of inadequacy in clinical proteomics is linked to samp...

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Bibliographic Details
Main Authors: Nicolas Molinari, Stéphane Roche, Katell Peoc’h, Laurent Tiers, Martial Séveno, Christophe Hirtz, Sylvain Lehmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
sample pooling
clinical proteomics
neurodegenerative disease
top–down
serum
CRP
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00477/full

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