Membrane cholesterol mediates the cellular effects of monolayer graphene substrates

Membrane cholesterol mediates the cellular effects of monolayer graphene substrates

Understanding the biological role of graphene in eukaryotic cells is essential for future biomedicine applications. Here, the authors investigate the interaction of neurons and fibroblasts with graphene substrates, which increase cell membrane cholesterol and potentiate neurotransmitter release and...

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Main Authors: Kristina E. Kitko, Tu Hong, Roman M. Lazarenko, Da Ying, Ya-Qiong Xu, Qi Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03185-0
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spelling doaj-105beac87f6b448d80369e21c2e69ecc2021-05-11T09:37:26ZengNature Publishing GroupNature Communications2041-17232018-02-019111710.1038/s41467-018-03185-0Membrane cholesterol mediates the cellular effects of monolayer graphene substratesKristina E. Kitko0Tu Hong1Roman M. Lazarenko2Da Ying3Ya-Qiong Xu4Qi Zhang5Department of Pharmacology, Vanderbilt UniversityDepartment of Electrical Engineering and Computer Science, Vanderbilt UniversityDepartment of Pharmacology, Vanderbilt UniversityDepartment of Electrical Engineering and Computer Science, Vanderbilt UniversityProgram in Interdisciplinary Materials Science, Vanderbilt UniversityDepartment of Pharmacology, Vanderbilt UniversityUnderstanding the biological role of graphene in eukaryotic cells is essential for future biomedicine applications. Here, the authors investigate the interaction of neurons and fibroblasts with graphene substrates, which increase cell membrane cholesterol and potentiate neurotransmitter release and receptor signaling.https://doi.org/10.1038/s41467-018-03185-0
collection DOAJ
language English
format Article
sources DOAJ
author Kristina E. Kitko
Tu Hong
Roman M. Lazarenko
Da Ying
Ya-Qiong Xu
Qi Zhang
spellingShingle Kristina E. Kitko
Tu Hong
Roman M. Lazarenko
Da Ying
Ya-Qiong Xu
Qi Zhang
Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
Nature Communications
author_facet Kristina E. Kitko
Tu Hong
Roman M. Lazarenko
Da Ying
Ya-Qiong Xu
Qi Zhang
author_sort Kristina E. Kitko
title Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
title_short Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
title_full Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
title_fullStr Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
title_full_unstemmed Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
title_sort membrane cholesterol mediates the cellular effects of monolayer graphene substrates
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description Understanding the biological role of graphene in eukaryotic cells is essential for future biomedicine applications. Here, the authors investigate the interaction of neurons and fibroblasts with graphene substrates, which increase cell membrane cholesterol and potentiate neurotransmitter release and receptor signaling.
url https://doi.org/10.1038/s41467-018-03185-0
work_keys_str_mv AT kristinaekitko membranecholesterolmediatesthecellulareffectsofmonolayergraphenesubstrates
AT tuhong membranecholesterolmediatesthecellulareffectsofmonolayergraphenesubstrates
AT romanmlazarenko membranecholesterolmediatesthecellulareffectsofmonolayergraphenesubstrates
AT daying membranecholesterolmediatesthecellulareffectsofmonolayergraphenesubstrates
AT yaqiongxu membranecholesterolmediatesthecellulareffectsofmonolayergraphenesubstrates
AT qizhang membranecholesterolmediatesthecellulareffectsofmonolayergraphenesubstrates
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