The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19

The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19

The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally i...

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Main Authors: Martina Di Maro, Mauro Cataldi, Mariarosaria Santillo, Martina Chiurazzi, Simona Damiano, Barbara De Conno, Antonio Colantuoni, Bruna Guida
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
severe acute respiratory syndrome coronavirus 2
lung
inflammation
nicotinic acetylcholine receptors
angiotensin-converting enzyme 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.653985/full
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spelling doaj-104ca124eb7d4806a87ba70b0d09f66b2021-05-13T04:45:23ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-05-011210.3389/fphys.2021.653985653985The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19Martina Di Maro0Mauro Cataldi1Mariarosaria Santillo2Martina Chiurazzi3Simona Damiano4Barbara De Conno5Antonio Colantuoni6Bruna Guida7Department of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, Division of Pharmacology, University of Naples Federico II, Naples, ItalyDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyDepartment of Clinical Medicine and Surgery, Physiology Nutrition Unit, University of Naples Federico II, Naples, ItalyThe renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally interact with each other, a mechanism that could have a more general physiological relevance than only COVID-19 infection.https://www.frontiersin.org/articles/10.3389/fphys.2021.653985/fullsevere acute respiratory syndrome coronavirus 2lunginflammationnicotinic acetylcholine receptorsangiotensin-converting enzyme 2
collection DOAJ
language English
format Article
sources DOAJ
author Martina Di Maro
Mauro Cataldi
Mariarosaria Santillo
Martina Chiurazzi
Simona Damiano
Barbara De Conno
Antonio Colantuoni
Bruna Guida
spellingShingle Martina Di Maro
Mauro Cataldi
Mariarosaria Santillo
Martina Chiurazzi
Simona Damiano
Barbara De Conno
Antonio Colantuoni
Bruna Guida
The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19
Frontiers in Physiology
severe acute respiratory syndrome coronavirus 2
lung
inflammation
nicotinic acetylcholine receptors
angiotensin-converting enzyme 2
author_facet Martina Di Maro
Mauro Cataldi
Mariarosaria Santillo
Martina Chiurazzi
Simona Damiano
Barbara De Conno
Antonio Colantuoni
Bruna Guida
author_sort Martina Di Maro
title The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19
title_short The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19
title_full The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19
title_fullStr The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19
title_full_unstemmed The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19
title_sort cholinergic and ace-2-dependent anti-inflammatory systems in the lung: new scenarios emerging from covid-19
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2021-05-01
description The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally interact with each other, a mechanism that could have a more general physiological relevance than only COVID-19 infection.
topic severe acute respiratory syndrome coronavirus 2
lung
inflammation
nicotinic acetylcholine receptors
angiotensin-converting enzyme 2
url https://www.frontiersin.org/articles/10.3389/fphys.2021.653985/full
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