Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK

Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their therapeutic benefits remain unclear. We previ...

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Bibliographic Details
Main Authors: Karolina A. Zielińska, Lode de Cauwer, Sofie Knoops, Kristof Van der Molen, Alexander Sneyers, Jonathan Thommis, J. Brian De Souza, Ghislain Opdenakker, Karolien De Bosscher, Philippe E. Van den Steen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
malaria
glucocorticoids
endothelium
MAPK
interferon-γ
dexamethasone
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01199/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01199/full

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