In Silico Prediction of PAMPA Effective Permeability Using a Two-QSAR Approach

In Silico Prediction of PAMPA Effective Permeability Using a Two-QSAR Approach

Oral administration is the preferred and predominant route of choice for medication. As such, drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) parameters that should be taken into consideration in the process of drug discovery and development. The cell-free in vitro pa...

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Bibliographic Details
Main Authors: Cheng-Ting Chi, Ming-Han Lee, Ching-Feng Weng, Max K. Leong
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
parallel artificial membrane permeability assay (PAMPA)
in silico
two-QSAR
hierarchical support vector regression
partial least square
effective permeability coefficient (<i>P</i><sub>e</sub>)
Online Access:https://www.mdpi.com/1422-0067/20/13/3170

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