Waist circumference does not predict circulating adiponectin levels in sub-Saharan women

<p>Abstract</p> <p>Background</p> <p>Because of previously reported ethnic differences in determinants and markers of obesity and related metabolic disorders, we sought to investigate circulating levels of adiponectin and their correlates in a sub-Saharan African (sSA)...

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Main Authors: Gautier Jean-François, Njamen Dieudonné, Boudou Philippe, Effoe Valery, Sobngwi Eugène, Mbanya Jean-Claude
Format: Article
Language:English
Published: BMC 2007-10-01
Series:Cardiovascular Diabetology
Online Access:http://www.cardiab.com/content/6/1/31
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spelling doaj-104230b1f20b43a3970b2ed2afbcfb9d2020-11-24T23:46:18ZengBMCCardiovascular Diabetology1475-28402007-10-01613110.1186/1475-2840-6-31Waist circumference does not predict circulating adiponectin levels in sub-Saharan womenGautier Jean-FrançoisNjamen DieudonnéBoudou PhilippeEffoe ValerySobngwi EugèneMbanya Jean-Claude<p>Abstract</p> <p>Background</p> <p>Because of previously reported ethnic differences in determinants and markers of obesity and related metabolic disorders, we sought to investigate circulating levels of adiponectin and their correlates in a sub-Saharan African (sSA) population.</p> <p>Subjects and Methods</p> <p>We studied 70 non-diabetic volunteers (33M/37F) living in Yaoundé, Cameroon, aged 24–69 yr, with BMI 20–42 kg/m<sup>2</sup>. In all participants we measured waist circumference and total body fat by bioimpedance, and obtained a fasting venous blood sample for measurement of plasma glucose, serum insulin and adiponectin concentrations. We performed a euglycaemic hyperinsulinaemic clamp in 1/4 subjects, and HOMA<sub>IR </sub>was used as surrogate of fasting insulin sensitivity index since it best correlates to clamp measurements.</p> <p>Results</p> <p>Males had lower adiponectin levels than females (8.8 ± 4.3 vs. 11.8 ± 5.5 μg/L). There was no significant correlation between adiponectin and total body fat (r<sub>s </sub>= -0.03; NS), whereas adiponectin was inversely correlated with waist circumference (r<sub>s </sub>= -0.39; p = 0.001). Adiponectin correlated negatively with insulin resistance (r<sub>s </sub>= -0.35; p = 0.01). In a regression analysis using fasting adiponectin concentration as the dependent variable, and age, HOMA<sub>IR</sub>, waist circumference, and fat mass as predictors, waist circumference (β = -3.30; p = 0.002), fat mass (β = -2.68; p = 0.01), and insulin resistance (β = -2.38; p = 0.02) but not age (β = 1.11; p = 0.27) were independent predictors of adiponectin. When considering gender, these relations persisted with the exception of waist circumference in females.</p> <p>Conclusion</p> <p>Adiponectin correlates in this study population are comparable to those observed in Caucasians with the exception of waist circumference in women. The metabolic significance of waist circumference is therefore questioned in sSA women.</p> http://www.cardiab.com/content/6/1/31
collection DOAJ
language English
format Article
sources DOAJ
author Gautier Jean-François
Njamen Dieudonné
Boudou Philippe
Effoe Valery
Sobngwi Eugène
Mbanya Jean-Claude
spellingShingle Gautier Jean-François
Njamen Dieudonné
Boudou Philippe
Effoe Valery
Sobngwi Eugène
Mbanya Jean-Claude
Waist circumference does not predict circulating adiponectin levels in sub-Saharan women
Cardiovascular Diabetology
author_facet Gautier Jean-François
Njamen Dieudonné
Boudou Philippe
Effoe Valery
Sobngwi Eugène
Mbanya Jean-Claude
author_sort Gautier Jean-François
title Waist circumference does not predict circulating adiponectin levels in sub-Saharan women
title_short Waist circumference does not predict circulating adiponectin levels in sub-Saharan women
title_full Waist circumference does not predict circulating adiponectin levels in sub-Saharan women
title_fullStr Waist circumference does not predict circulating adiponectin levels in sub-Saharan women
title_full_unstemmed Waist circumference does not predict circulating adiponectin levels in sub-Saharan women
title_sort waist circumference does not predict circulating adiponectin levels in sub-saharan women
publisher BMC
series Cardiovascular Diabetology
issn 1475-2840
publishDate 2007-10-01
description <p>Abstract</p> <p>Background</p> <p>Because of previously reported ethnic differences in determinants and markers of obesity and related metabolic disorders, we sought to investigate circulating levels of adiponectin and their correlates in a sub-Saharan African (sSA) population.</p> <p>Subjects and Methods</p> <p>We studied 70 non-diabetic volunteers (33M/37F) living in Yaoundé, Cameroon, aged 24–69 yr, with BMI 20–42 kg/m<sup>2</sup>. In all participants we measured waist circumference and total body fat by bioimpedance, and obtained a fasting venous blood sample for measurement of plasma glucose, serum insulin and adiponectin concentrations. We performed a euglycaemic hyperinsulinaemic clamp in 1/4 subjects, and HOMA<sub>IR </sub>was used as surrogate of fasting insulin sensitivity index since it best correlates to clamp measurements.</p> <p>Results</p> <p>Males had lower adiponectin levels than females (8.8 ± 4.3 vs. 11.8 ± 5.5 μg/L). There was no significant correlation between adiponectin and total body fat (r<sub>s </sub>= -0.03; NS), whereas adiponectin was inversely correlated with waist circumference (r<sub>s </sub>= -0.39; p = 0.001). Adiponectin correlated negatively with insulin resistance (r<sub>s </sub>= -0.35; p = 0.01). In a regression analysis using fasting adiponectin concentration as the dependent variable, and age, HOMA<sub>IR</sub>, waist circumference, and fat mass as predictors, waist circumference (β = -3.30; p = 0.002), fat mass (β = -2.68; p = 0.01), and insulin resistance (β = -2.38; p = 0.02) but not age (β = 1.11; p = 0.27) were independent predictors of adiponectin. When considering gender, these relations persisted with the exception of waist circumference in females.</p> <p>Conclusion</p> <p>Adiponectin correlates in this study population are comparable to those observed in Caucasians with the exception of waist circumference in women. The metabolic significance of waist circumference is therefore questioned in sSA women.</p>
url http://www.cardiab.com/content/6/1/31
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