| Summary: | Purpose: To test the hypothesis that human eyes have a central tendency to be free of higher-order aberrations by analyzing wavefront aberrations for two young populations of respectively emmetropic and myopic subjects.
Methods: Both right and left eyes of 75 emmetropes and 196 myopes were measured for corneal wavefront aberration using a Humphrey corneal topographer and for the whole eye wavefront aberration using a WASCA wavefront sensor without pupil dilation. 35 Zernike aberration coefficients over a 6.0 mm pupil diameter were derived, and statistics of the higher-order terms (3rd to 5th orders) were tested.
Results: When signed Zernike aberrations of the right and left eyes were averaged together for the emmetropes, three higher-order modes (j=6, 12 and 13) were significantly different from zero in both the cornea and the whole eye (P<0.0005), and three additional terms (j=14, 15 and 17) were statistically non-zero for the whole eye. As the signs of y-axis asymmetrical terms in the left eye were flipped, three more terms in either the cornea (j=8, 18 and 19) or the whole eye (j=8, 10 and 20) became statistically non-zero. For the myopes, 8 corneal terms and 5 whole-eye terms were statistically non-zero when the two eyes were averaged together. As the signs flipped, the majority of the Zernike aberration terms were statistically different from zero.
Conclusions: Human eyes have systematical higher order aberrations in population, and factors that cause bilateral symmetry of wavefront aberrations between the right and left eyes made important contribution to the systematical aberrations.
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