Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro

Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro

Upon cardiac pathological conditions such as ischemia, microenvironmental changes instruct a series of cellular responses that trigger cardiac fibroblasts-mediated tissue adaptation and inflammation. A comprehensive model of how early environmental changes may induce cardiac fibroblasts (CF) patholo...

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Bibliographic Details
Main Authors: Giovanni Stefano Ugolini, Andrea Pavesi, Marco Rasponi, Gianfranco Beniamino Fiore, Roger Kamm, Monica Soncini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
cardiac remodeling
cardiac fibroblasts
pathological modeling
organs-on-chip
Online Access:https://elifesciences.org/articles/22847

Internet

https://elifesciences.org/articles/22847

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