Effect of Probiotic Administration on Serum Tryptophan Metabolites in Pediatric Type 1 Diabetes Patients

Type 1 diabetes (T1D) is characterized by anomalous functioning of the immuno regulatory, tryptophan-catabolic enzyme indoleamine 2,3 dioxygenase 1 (IDO1). In T1D, the levels of kynurenine—the first byproduct of tryptophan degradation via IDO1—are significantly lower than in nondiabetic controls, su...

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Bibliographic Details
Main Authors: Giada Mondanelli, Elena Orecchini, Claudia Volpi, Eleonora Panfili, Maria Laura Belladonna, Maria Teresa Pallotta, Simone Moretti, Roberta Galarini, Susanna Esposito, Ciriana Orabona
Format: Article
Language:English
Published: SAGE Publishing 2020-09-01
Series:International Journal of Tryptophan Research
Online Access:https://doi.org/10.1177/1178646920956646