On-treatment improvement of an emerging psychosomatic depressive disorder among salmonella carriers: a multicenter experience from Egypt

• Main Authors: Bakeer MS, Youssef MI, Elshazly HM, Abdel-Samiee M, El-Gendy AA, Abouzed M, Othman W, Abdelkareem M, Abozeid M, Awad SM, Khalil FO, Bedair HM, Diab KA, Seif AS, Youssef MF, Sakr AA, Abdelsameea E
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-08-01
• Series: Infection and Drug Resistance
• Subjects: Psychosomatic; Depression; Typhoid Carriers; Egypt
• Online Access: https://www.dovepress.com/on-treatment-improvement-of-an-emerging-psychosomatic-depressive-disor-peer-reviewed-article-IDR

Mohammed Saied Bakeer,1 Mohamed Ibrahim Youssef,1 Helmy M Elshazly,2 Mohamed Abdel-Samiee,2 Abdelaleem A El-Gendy,3 M Abouzed,4 Warda Othman,2 Mervat Abdelkareem,2 Mai Abozeid,2 Samah Mohammed Awad,5 Fatma O Khalil,5 Hanan M Bedair,6 Karema A Diab,6 A S Seif,7 Marwa F Youssef,8 Ayman Ahmed Sakr,9 Eman Abdelsameea21Internal Medicine Department, Al-Azhar University, Cairo, Egypt; 2Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Menoufia, Egypt; 3Clinical Pathology Department, Al-Azhar University, Cairo, Egypt; 4Psychiatry Department, Al-Azhar University, Cairo, Egypt; 5Clinical Microbiology and Immunology and Molecular Microbiology in Liver and GIT Department, National Liver Institute, Menoufia University, Menoufia, Egypt; 6Clinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt; 7Tropical Medicine Hepatology and Gastroenterology Department, Shebin Elkom Teaching Hospital, Menoufia, Egypt; 8Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Menoufia, Egypt; 9Tropical Medicine Department, Faculty of Medicine, Menoufia University, Menoufia, EgyptCorrespondence: Mohamed Abdel-SamieeHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, 32511 Shebin El-kom, Menoufia, EgyptEmail [e-mail]: As physicians in a referral hospital, we observed the association between history of enteric fever and somatic disorders associated with low mood. At the Al-Hussein University Hospital, Cairo and the National Liver Institute Hospital, Menoufia, we receive patients from all over Egypt, including rural areas where enteric fever is endemic.Aim: Here in, 60 Egyptian patients referred to us for evaluation of different somatic disorders are reported.Methods: After extensive evaluations, the patients’ symptoms were function-related. Also, their typhoid carrier states were documented, and the severity of depression using Hamilton-D (HAM-D) questionnaire was evaluated and recorded. All patients were treated with ceftriaxone, 2 gm, IV, daily for 15 days. The clinical evaluation and Hamilton score were reassessed at the end of the treatment and 6 weeks thereafter. The patients did not receive any anti-depressant nor anti-anxiety treatment during their course. Typhoid carrier was defined by documenting the history of typhoid fever that was diagnosed by culturing the Salmonella species, and not by serology, isolated from stool culture along with febrile condition, plus the absence of fever in the past 3 weeks. The Widal test was not accepted as a criterion for enrollment.Results: Patients showed clinically significant improvement in the somatic complaints, and their HAM-D score immediately post-treatment that was consolidated for 6 weeks post-treatment completion.Conclusion: In this study, the typhoid carrier was associated with the psychosomatic depression that improved by antibiotic therapy.Keywords: psychosomatic, depression, typhoid carriers, Egypt