Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression

Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression

The alteration of glucose metabolism, through increased uptake of glucose and glutamine addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through the Hexosamine Biosynthetic Pathway (HBP) drives increased cellular O-GlcNAcylation (hyper-O-GlcNAcylation) and contri...

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Bibliographic Details
Main Authors: Muhammad Tariq Saeed, Jamil Ahmad, Shahzina Kanwal, Andreana N. Holowatyj, Iftikhar A. Sheikh, Rehan Zafar Paracha, Aamir Shafi, Amnah Siddiqa, Zurah Bibi, Mukaram Khan, Amjad Ali
Format: Article
Language:English
Published: PeerJ Inc. 2016-09-01
Series:PeerJ
Subjects:
Biological regulatory networks (BRNs)
René Thomas
Qualitative modeling
Model checking
Cancer
Hexosamine biosynthetic pathway
Online Access:https://peerj.com/articles/2348.pdf

Internet

https://peerj.com/articles/2348.pdf

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