Excessive cytosolic DNA fragments as a potential trigger of Graves’ disease: an encrypted message sent by animal models

Excessive cytosolic DNA fragments as a potential trigger of Graves’ disease: an encrypted message sent by animal models

Graves’ hyperthyroidism is caused by autoantibodies directed against the thyroid stimulating hormone receptor (TSHR) that mimic the action of TSH. The establishment of Graves’ hyperthyroidism in experimental animals has proven to be an important approach to dissect the mechanisms of self-tolerance b...

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Bibliographic Details
Main Authors: Yuqian Luo, Aya Yoshihara, Kenzaburo Oda, Yuko Ishido, Koichi Suzuki
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Endocrinology
Subjects:
experimental animal models
major histocompatibility complex class II
Genomic DNA
Thyroid stimulating hormone receptor
Graves’ disease
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00144/full

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