The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin

Objectives This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondi...

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Main Authors: Yuksel Toplu, Emrah Sapmaz, Hakan Parlakpinar, Mehmet Kelles, M. Tayyar Kalcioglu, Kevser Tanbek, Ahmet Kizilay
Format: Article
Language:English
Published: Korean Society of Otorhinolaryngology-Head and Neck Surgery 2016-03-01
Series:Clinical and Experimental Otorhinolaryngology
Subjects:
Online Access:http://www.e-ceo.org/upload/pdf/ceo-2016-9-1-14.pdf
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spelling doaj-1016f1b6920f470db0ae553e83b985bf2020-11-24T23:20:55ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202016-03-0191142010.21053/ceo.2016.9.1.14423The Effect of Dexpanthenol on Ototoxicity Induced by CisplatinYuksel Toplu0Emrah Sapmaz1Hakan Parlakpinar2Mehmet Kelles3M. Tayyar Kalcioglu4Kevser Tanbek5Ahmet Kizilay6 Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey Department of Otorhinolaryngology, Malatya State Hospital, Malatya, Turkey Department of Pharmacology, Inonu University Medical Faculty, Malatya, Turkey Department of Otorhinolaryngology, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey Department of Otorhinolaryngology, Istanbul Medeniyet University Medical Faculty, Istanbul, Turkey Department of Physiology, Inonu University Medical Faculty, Malatya, Turkey Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, TurkeyObjectives This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion According to these results, Dxp may prevent cisplatin-induced ototoxicity.http://www.e-ceo.org/upload/pdf/ceo-2016-9-1-14.pdfCisplatinOtotoxicityDexpanthenolOtoacoustic EmissionsBiomarkers
collection DOAJ
language English
format Article
sources DOAJ
author Yuksel Toplu
Emrah Sapmaz
Hakan Parlakpinar
Mehmet Kelles
M. Tayyar Kalcioglu
Kevser Tanbek
Ahmet Kizilay
spellingShingle Yuksel Toplu
Emrah Sapmaz
Hakan Parlakpinar
Mehmet Kelles
M. Tayyar Kalcioglu
Kevser Tanbek
Ahmet Kizilay
The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
Clinical and Experimental Otorhinolaryngology
Cisplatin
Ototoxicity
Dexpanthenol
Otoacoustic Emissions
Biomarkers
author_facet Yuksel Toplu
Emrah Sapmaz
Hakan Parlakpinar
Mehmet Kelles
M. Tayyar Kalcioglu
Kevser Tanbek
Ahmet Kizilay
author_sort Yuksel Toplu
title The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
title_short The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
title_full The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
title_fullStr The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
title_full_unstemmed The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
title_sort effect of dexpanthenol on ototoxicity induced by cisplatin
publisher Korean Society of Otorhinolaryngology-Head and Neck Surgery
series Clinical and Experimental Otorhinolaryngology
issn 1976-8710
2005-0720
publishDate 2016-03-01
description Objectives This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion According to these results, Dxp may prevent cisplatin-induced ototoxicity.
topic Cisplatin
Ototoxicity
Dexpanthenol
Otoacoustic Emissions
Biomarkers
url http://www.e-ceo.org/upload/pdf/ceo-2016-9-1-14.pdf
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