The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin
Objectives This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondi...
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
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doaj-1016f1b6920f470db0ae553e83b985bf2020-11-24T23:20:55ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202016-03-0191142010.21053/ceo.2016.9.1.14423The Effect of Dexpanthenol on Ototoxicity Induced by CisplatinYuksel Toplu0Emrah Sapmaz1Hakan Parlakpinar2Mehmet Kelles3M. Tayyar Kalcioglu4Kevser Tanbek5Ahmet Kizilay6 Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey Department of Otorhinolaryngology, Malatya State Hospital, Malatya, Turkey Department of Pharmacology, Inonu University Medical Faculty, Malatya, Turkey Department of Otorhinolaryngology, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey Department of Otorhinolaryngology, Istanbul Medeniyet University Medical Faculty, Istanbul, Turkey Department of Physiology, Inonu University Medical Faculty, Malatya, Turkey Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, TurkeyObjectives This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion According to these results, Dxp may prevent cisplatin-induced ototoxicity.http://www.e-ceo.org/upload/pdf/ceo-2016-9-1-14.pdfCisplatinOtotoxicityDexpanthenolOtoacoustic EmissionsBiomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuksel Toplu Emrah Sapmaz Hakan Parlakpinar Mehmet Kelles M. Tayyar Kalcioglu Kevser Tanbek Ahmet Kizilay |
spellingShingle |
Yuksel Toplu Emrah Sapmaz Hakan Parlakpinar Mehmet Kelles M. Tayyar Kalcioglu Kevser Tanbek Ahmet Kizilay The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin Clinical and Experimental Otorhinolaryngology Cisplatin Ototoxicity Dexpanthenol Otoacoustic Emissions Biomarkers |
author_facet |
Yuksel Toplu Emrah Sapmaz Hakan Parlakpinar Mehmet Kelles M. Tayyar Kalcioglu Kevser Tanbek Ahmet Kizilay |
author_sort |
Yuksel Toplu |
title |
The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin |
title_short |
The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin |
title_full |
The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin |
title_fullStr |
The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin |
title_full_unstemmed |
The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin |
title_sort |
effect of dexpanthenol on ototoxicity induced by cisplatin |
publisher |
Korean Society of Otorhinolaryngology-Head and Neck Surgery |
series |
Clinical and Experimental Otorhinolaryngology |
issn |
1976-8710 2005-0720 |
publishDate |
2016-03-01 |
description |
Objectives This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. Conclusion According to these results, Dxp may prevent cisplatin-induced ototoxicity. |
topic |
Cisplatin Ototoxicity Dexpanthenol Otoacoustic Emissions Biomarkers |
url |
http://www.e-ceo.org/upload/pdf/ceo-2016-9-1-14.pdf |
work_keys_str_mv |
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