SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia

SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia

Abstract Background Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer. Both animal and clinical studies have revealed that bile acid reflux and subsequent chronic inflammation are key causal factors of IM. Previous studies indicated that SOX2, the key transcription f...

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Bibliographic Details
Main Authors: Ting Yuan, Zhen Ni, Chuan Han, Yali Min, Nina Sun, Caifang Liu, Miao Shi, Wenquan Lu, Na Wang, Feng Du, Qiong Wu, Ning Xie, Yongquan Shi
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cancer Cell International
Subjects:
Bile acid
CDX2
Intestinal metaplasia
miR-21
SOX2
Online Access:http://link.springer.com/article/10.1186/s12935-019-0739-8

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