Kynurenine pathway metabolites selectively associate with impaired associative memory function in depression

Kynurenine pathway metabolites selectively associate with impaired associative memory function in depression

Activation of the kynurenine pathway (KP), an important downstream effect of inflammation, is a driver of depression and neurodegeneration. Damage from the end product of KP activation, quinolinic acid, may be responsible specifically for impairment in hippocampally mediated memory function, among i...

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Bibliographic Details
Main Authors: Margherita Chirico, James Custer, Ifeoluwa Shoyombo, Crystal Cooper, Sheila Meldrum, Robert Dantzer, Madhukar H. Trivedi, Paul Rathouz, Marisa S. Toups
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Depression
Memory
Cognition
Kynurenine
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300910

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