Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate

Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate

PLGA (Lactic- co-glycolic acid) coated chitosan microspheres loaded with hydroxyapatite and doxycycline hyclate complex were developed in the present study for periodontal delivery. A modified single emulsion method was adopted for the development of microspheres. Formulation was optimized on the ba...

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Bibliographic Details
Main Authors: Pooja Jain, Abhinav Garg, Uzma Farooq, Amulya K. Panda, Mohd. Aamir Mirza, Ahmed Noureldeen, Hadeer Darwish, Zeenat Iqbal
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Saudi Journal of Biological Sciences
Subjects:
Bioceramic
Composite
Quality by design
Central composite design
Microspheres
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X21002175

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