Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

<b>: </b>Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment. During a fractionated radiat...

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Bibliographic Details
Main Authors: Apostolos Menegakis, Rob Klompmaker, Claire Vennin, Aina Arbusà, Maartje Damen, Bram van den Broek, Daniel Zips, Jacco van Rheenen, Lenno Krenning, René H. Medema
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
hypoxia
G1-arrest
quiescence
radiation resistance
HPV
Online Access:https://www.mdpi.com/2073-4409/10/3/610

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