Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways

Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways

Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron brev...

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Bibliographic Details
Main Authors: Chao-Yue Sun, Ying Zhu, Xiao-Feng Li, Xie-Qi Wang, Li-Peng Tang, Zu-Qing Su, Cai-Yun Li, Guang-Juan Zheng, Bing Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
scutellarin
cisplatin
NSCLC
apoptosis
autophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00092/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00092/full

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