The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: a network meta-analysis

Abstract Background Osteosarcoma, a primary malignant bone tumor derived from mesenchymal tissue, is the most common type of pleomorphic tumor that occurs in children and adolescents. The aim of this study was to compare the efficacy and safety of high-dose methotrexate (M), doxorubicin (D), cisplat...

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Bibliographic Details
Main Authors: Bin Zhang, Yan Zhang, Rongzhen Li, Jiazhen Li, Xinchang Lu, Yi Zhang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-020-1576-0