Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection

Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α4-Short, in a Murine Model of Respiratory Infection

The rise of superbugs underscores the urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) have the ability to kill superbugs regardless of resistance to traditional antibiotics. However, AMPs often display a lack of efficacy in vivo. Sequence optimization and engineering are pr...

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Bibliographic Details
Main Authors: Shasha Jiang, Berthony Deslouches, Chen Chen, Matthew E. Di, Y. Peter Di
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
SPLUNC1
airway infection
antibiotic resistance
antimicrobial peptides
biofilm
broad spectrum
drug resistance
in vivo efficacy
multidrug-resistant bacteria
peptide antibiotics
pneumonia
selective toxicity
Online Access:https://doi.org/10.1128/mBio.00226-19

Internet

https://doi.org/10.1128/mBio.00226-19

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