Effect of hydromorphone hydrochloride postoperative analgesia on the inflammatory cytokines, S-100β, and NSE in elderly patients after total hip replacement

• Main Authors: Kan Li, Long Jiang, Xiuhui Fu, Jingjing Zhang, Guangyuan Li, Yanchun Zhao, Qing Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Hydromorphone hydrochloride; Postoperative analgesia; Elderly THR; Inflammatory cytokine; S-100β; NSE
• Online Access: http://www.hnykdxxb.com/PDF/201704/26.pdf

Objective: To explore the effect of hydromorphone hydrochloride postoperative analgesia on the inflammatory cytokines, S-100毬, and NSE in elderly patients after total hip replacement (THR). Methods: A total of 100 patients who were admitted in our hospital from January, 2015 to July, 2016 for THR were included in the study and randomized into the observation group and the control group with 50 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride (0.3 mg) + dexamethasone (5 mg) + normal saline (100 mL), while the patients in the control group were given sufentanil (150 μg) + dexamethasone (5 mg) + normal saline (100 mL). The morning fasting peripheral venous blood before operation, 24 h and 3 d after operation in the two groups was collected. ELISA was used to detect the serum CRP, IL-6, and TNF-毩, and the plasma S-100毬 and NSE levels. Results: The serum CRP, TNF-毩, and IL-6 levels 24 h and 3 d after operation in the two groups were significantly elevated when compared with before operation, and were reduced 3d after operation. CRP, TNF-毩, and IL-6 levels at each timing point after operation in the observation group were significantly lower than those in the control group. The plasma S-100毬 and NSE levels 24 h and 3 d after operation in the two groups were significantly elevated when compared with before operation, and were reduced 3 d after operation. The plasma S-100毬 and NSE levels at each timing point after operation in the observation group were significantly lower than those in the control group. Conclusions: Hydromorphone hydrochloride can relieve the postoperative pain in elderly patients with THR, effectively alleviate the inflammatory reaction, reduce the plasma S-100毬 and NSE levels, and alleviate the cerebral injury, whose pathogenesis remains a further deep study.