An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity

An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity

Chimeric antigen receptors (CARs) are synthetic receptors that usually redirect T cells to surface antigens independent of human leukocyte antigen (HLA). Here, we investigated a T cell receptor-like CAR based on an antibody that recognizes HLA-A*0201 presenting a peptide epitope derived from the can...

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Bibliographic Details
Main Authors: Marcela V Maus, Jason Plotkin, Gopinadh Jakka, Guillaume Stewart-Jones, Isabelle Rivière, Taha Merghoub, Jedd Wolchok, Christoph Renner, Michel Sadelain
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300602

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http://www.sciencedirect.com/science/article/pii/S2372770516300602

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