The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer

The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer

Many estrogen receptor (ER)-positive breast cancers develop resistance to endocrine therapy but retain canonical receptor signalling in the presence of selective ER antagonists. Numerous co-regulatory proteins, including enzymes that modulate the chromatin environment, control the transcriptional ac...

Full description

Bibliographic Details
Main Authors: Dominic Jones, Laura Wilson, Huw Thomas, Luke Gaughan, Mark A. Wade
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
epigenetics
histone demethylation
estrogen receptor
breast cancer
Online Access:https://www.mdpi.com/2072-6694/11/8/1122

Similar Items

Similar Items