Design and High Expression of Non-glycosylated Lysostaphins in Pichia pastoris and Their Pharmacodynamic Study

Design and High Expression of Non-glycosylated Lysostaphins in Pichia pastoris and Their Pharmacodynamic Study

Lysostaphin is an effective antimicrobial agent to Staphylococcus, especially for the methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Staphylococcus aureus (MDRSA). In this study, the seven lysostaphin derived mutants (rLys) were designed to overcome the barrier of glycosy...

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Bibliographic Details
Main Authors: Wenluan Shen, Na Yang, Da Teng, Ya Hao, Xuanxuan Ma, Ruoyu Mao, Jianhua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Microbiology
Subjects:
lysostaphins
non-glycosylation
P. pastoris expression
sepsis mouse model
pharmacodynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.637662/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.637662/full

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