Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms

We present a nonlinear optical crystal (NLOC)-based terahertz (THz) microfluidic chip with a few arrays of split ring resonators (SRRs) for ultra-trace and quantitative measurements of liquid solutions. The proposed chip operates on the basis of near-field coupling between the SRRs and a local emiss...

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Main Authors: Kazunori Serita, Eiki Matsuda, Kosuke Okada, Hironaru Murakami, Iwao Kawayama, Masayoshi Tonouchi
Format: Article
Language:English
Published: AIP Publishing LLC 2018-05-01
Series:APL Photonics
Online Access:http://dx.doi.org/10.1063/1.5007681
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spelling doaj-0fdb381f81584ccfad16bd616a7bacb72020-11-24T23:42:44ZengAIP Publishing LLCAPL Photonics2378-09672018-05-0135051603051603-1010.1063/1.5007681006891APPInvited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atomsKazunori Serita0Eiki Matsuda1Kosuke Okada2Hironaru Murakami3Iwao Kawayama4Masayoshi Tonouchi5Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, JapanInstitute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, JapanInstitute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, JapanInstitute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, JapanInstitute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, JapanInstitute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, JapanWe present a nonlinear optical crystal (NLOC)-based terahertz (THz) microfluidic chip with a few arrays of split ring resonators (SRRs) for ultra-trace and quantitative measurements of liquid solutions. The proposed chip operates on the basis of near-field coupling between the SRRs and a local emission of point like THz source that is generated in the process of optical rectification in NLOCs on a sub-wavelength scale. The liquid solutions flowing inside the microchannel modify the resonance frequency and peak attenuation in the THz transmission spectra. In contrast to conventional bio-sensing with far/near-field THz waves, our technique can be expected to compactify the chip design as well as realize high sensitive near-field measurement of liquid solutions without any high-power optical/THz source, near-field probes, and prisms. Using this chip, we have succeeded in observing the 31.8 fmol of ion concentration in actual amount of 318 pl water solutions from the shift of the resonance frequency. The technique opens the door to microanalysis of biological samples with THz waves and accelerates development of THz lab-on-chip devices.http://dx.doi.org/10.1063/1.5007681
collection DOAJ
language English
format Article
sources DOAJ
author Kazunori Serita
Eiki Matsuda
Kosuke Okada
Hironaru Murakami
Iwao Kawayama
Masayoshi Tonouchi
spellingShingle Kazunori Serita
Eiki Matsuda
Kosuke Okada
Hironaru Murakami
Iwao Kawayama
Masayoshi Tonouchi
Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
APL Photonics
author_facet Kazunori Serita
Eiki Matsuda
Kosuke Okada
Hironaru Murakami
Iwao Kawayama
Masayoshi Tonouchi
author_sort Kazunori Serita
title Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
title_short Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
title_full Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
title_fullStr Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
title_full_unstemmed Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
title_sort invited article: terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
publisher AIP Publishing LLC
series APL Photonics
issn 2378-0967
publishDate 2018-05-01
description We present a nonlinear optical crystal (NLOC)-based terahertz (THz) microfluidic chip with a few arrays of split ring resonators (SRRs) for ultra-trace and quantitative measurements of liquid solutions. The proposed chip operates on the basis of near-field coupling between the SRRs and a local emission of point like THz source that is generated in the process of optical rectification in NLOCs on a sub-wavelength scale. The liquid solutions flowing inside the microchannel modify the resonance frequency and peak attenuation in the THz transmission spectra. In contrast to conventional bio-sensing with far/near-field THz waves, our technique can be expected to compactify the chip design as well as realize high sensitive near-field measurement of liquid solutions without any high-power optical/THz source, near-field probes, and prisms. Using this chip, we have succeeded in observing the 31.8 fmol of ion concentration in actual amount of 318 pl water solutions from the shift of the resonance frequency. The technique opens the door to microanalysis of biological samples with THz waves and accelerates development of THz lab-on-chip devices.
url http://dx.doi.org/10.1063/1.5007681
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