Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol

Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol

Side chain oxysterols are cholesterol derivatives thought to signal the abundance of cell cholesterol to homeostatic effector proteins. Here, we investigated how plasma membrane (PM) cholesterol might regulate 27-hydroxycholesterol (HC) biosynthesis in cultured fibroblasts. We showed that PM cholest...

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Bibliographic Details
Main Authors: Yvonne Lange, Theodore L. Steck, Jin Ye, Michael H. Lanier, Vasumathi Molugu, Daniel Ory
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Journal of Lipid Research
Subjects:
homeostasis
endoplasmic reticulum
oxysterol
feedback
Niemann-Pick
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520307409

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http://www.sciencedirect.com/science/article/pii/S0022227520307409

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