An Evolutionary Perspective of Animal MicroRNAs and Their Targets
MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRN...
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Hindawi Limited
2009-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/2009/594738 |
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doaj-0fda822360c244e090e57c421f2b9af92020-11-25T00:51:26ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512009-01-01200910.1155/2009/594738594738An Evolutionary Perspective of Animal MicroRNAs and Their TargetsNoam Shomron0David Golan1Eran Hornstein2Department of Cell & Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelDepartment of Cell & Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, IsraelMicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs.http://dx.doi.org/10.1155/2009/594738 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Noam Shomron David Golan Eran Hornstein |
| spellingShingle |
Noam Shomron David Golan Eran Hornstein An Evolutionary Perspective of Animal MicroRNAs and Their Targets Journal of Biomedicine and Biotechnology |
| author_facet |
Noam Shomron David Golan Eran Hornstein |
| author_sort |
Noam Shomron |
| title |
An Evolutionary Perspective of Animal MicroRNAs and Their Targets |
| title_short |
An Evolutionary Perspective of Animal MicroRNAs and Their Targets |
| title_full |
An Evolutionary Perspective of Animal MicroRNAs and Their Targets |
| title_fullStr |
An Evolutionary Perspective of Animal MicroRNAs and Their Targets |
| title_full_unstemmed |
An Evolutionary Perspective of Animal MicroRNAs and Their Targets |
| title_sort |
evolutionary perspective of animal micrornas and their targets |
| publisher |
Hindawi Limited |
| series |
Journal of Biomedicine and Biotechnology |
| issn |
1110-7243 1110-7251 |
| publishDate |
2009-01-01 |
| description |
MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through translational inhibition or mRNA degradation by binding to sequences on the target mRNA. miRNA regulation appears to be the most abundant mode of posttranscriptional regulation affecting ∼50% of the transcriptome. miRNA genes are often clustered and/or located in introns, and each targets a variable and often large number of mRNAs. Here we discuss the genomic architecture of animal miRNA genes and their evolving interaction with their target mRNAs. |
| url |
http://dx.doi.org/10.1155/2009/594738 |
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