Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model

IntroductionHypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways. Therefore, we investigated whether the combination...

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Bibliographic Details
Main Authors: Sylvia J. Wowro, Giang Tong, Jana Krech, Nele Rolfs, Felix Berger, Katharina R. L. Schmitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cyclosporin A
hypothermia
oxygen-glucose deprivation/reperfusion
organotypic hippocampal slice culture
BV-2 microglia
primary neuron
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00273/full

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