Expression of Signal Transducer and Activator of Transcription 3 and Suppressor of Cytokine Signaling 3 in Urothelial Carcinoma

• Main Authors: Wan-Ting Huang, Sheau-Fang Yang, Chun-Chieh Wu, Wan-Tzu Chen, Ya-Chun Huang, Yue-Chiu Su, Chee-Yin Chai
• Format: Article
• Language: English
• Published: Wiley 2009-12-01
• Series: Kaohsiung Journal of Medical Sciences
• Subjects: immunohistochemical staining; p-STAT3; SOCS3; tissue microarray; urothelial carcinoma
• Online Access: http://www.sciencedirect.com/science/article/pii/S1607551X09705698

In this study, we investigated the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) Tyr705 and suppressor of cytokine signaling 3 (SOCS3) in urothelial carcinoma (UC). p-STAT3 (Tyr705) and SOCS3 were analyzed by immunohistochemistry using tissue microarray and Western blotting. Our results showed that p-STAT3 (Tyr705) was frequently detected in high-grade and infiltrating UC. However, there was no difference in p-STAT3 (Tyr705) staining between UC of the upper and lower urinary tracts. In addition, there was no significant correlation between expression of SOCS3 and histological differentiation and invasiveness of UC. These findings suggest that overexpression of p-STAT3 (Tyr705) occurs in UC, and that pathways other than SOCS3 may contribute to its activation in this cancer.