The mutational landscape of a prion-like domain

The mutational landscape of a prion-like domain

TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation o...

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Main Authors: Benedetta Bolognesi, Andre J. Faure, Mireia Seuma, Jörn M. Schmiedel, Gian Gaetano Tartaglia, Ben Lehner
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12101-z
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spelling doaj-0fca2a044c88458bacfb8b409c6af5b72021-05-11T11:38:51ZengNature Publishing GroupNature Communications2041-17232019-09-0110111210.1038/s41467-019-12101-zThe mutational landscape of a prion-like domainBenedetta Bolognesi0Andre J. Faure1Mireia Seuma2Jörn M. Schmiedel3Gian Gaetano Tartaglia4Ben Lehner5Center for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCenter for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCenter for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCenter for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCenter for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCenter for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyTDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation of TDP43 is protective for the cell.https://doi.org/10.1038/s41467-019-12101-z
collection DOAJ
language English
format Article
sources DOAJ
author Benedetta Bolognesi
Andre J. Faure
Mireia Seuma
Jörn M. Schmiedel
Gian Gaetano Tartaglia
Ben Lehner
spellingShingle Benedetta Bolognesi
Andre J. Faure
Mireia Seuma
Jörn M. Schmiedel
Gian Gaetano Tartaglia
Ben Lehner
The mutational landscape of a prion-like domain
Nature Communications
author_facet Benedetta Bolognesi
Andre J. Faure
Mireia Seuma
Jörn M. Schmiedel
Gian Gaetano Tartaglia
Ben Lehner
author_sort Benedetta Bolognesi
title The mutational landscape of a prion-like domain
title_short The mutational landscape of a prion-like domain
title_full The mutational landscape of a prion-like domain
title_fullStr The mutational landscape of a prion-like domain
title_full_unstemmed The mutational landscape of a prion-like domain
title_sort mutational landscape of a prion-like domain
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation of TDP43 is protective for the cell.
url https://doi.org/10.1038/s41467-019-12101-z
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