Mechanistic modeling of aberrant energy metabolism in human disease

Mechanistic modeling of aberrant energy metabolism in human disease

Dysfunction in energy metabolism—including in pathways localized to the mitochondria—has been implicated in the pathogenesis of a wide array of disorders, ranging from cancer to neurodegenerative diseases to type II diabetes. The inherent complexities of energy and mitochondrial metabolism present a...

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Bibliographic Details
Main Authors: Vineet eSangar, James Allan Eddy, Evangelos eSimeonidis, Nathan ePrice
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Physiology
Subjects:
Energy Metabolism
Mitochondria
Systems Biology
Flux balance analysis
stoichiometric models
Warburg effect
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00404/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00404/full

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