Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.

Bibliographic Details
Main Authors:	Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00952-3

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spelling	doaj-0fc143dfc7464c2e803e239b8d4ccb422021-05-11T07:57:55ZengNature Publishing GroupNature Communications2041-17232017-10-01811910.1038/s41467-017-00952-3Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brainY. Anraku0H. Kuwahara1Y. Fukusato2A. Mizoguchi3T. Ishii4K. Nitta5Y. Matsumoto6K. Toh7K. Miyata8S. Uchida9K. Nishina10K. Osada11K. Itaka12N. Nishiyama13H. Mizusawa14T. Yamasoba15T. Yokota16K. Kataoka17Department of Bioengineering, Graduate School of Engineering, The University of TokyoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)Department of Bioengineering, Graduate School of Engineering, The University of TokyoCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoDepartment of Bioengineering, Graduate School of Engineering, The University of TokyoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoInnovation Center of NanoMedicine, Kawasaki Institute of Industrial PromotionCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoDepartment of Bioengineering, Graduate School of Engineering, The University of TokyoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)Department of Bioengineering, Graduate School of Engineering, The University of TokyoCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of TokyoLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of TechnologyDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, The University of TokyoDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)Innovation Center of NanoMedicine, Kawasaki Institute of Industrial PromotionThere are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.https://doi.org/10.1038/s41467-017-00952-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Y. Anraku H. Kuwahara Y. Fukusato A. Mizoguchi T. Ishii K. Nitta Y. Matsumoto K. Toh K. Miyata S. Uchida K. Nishina K. Osada K. Itaka N. Nishiyama H. Mizusawa T. Yamasoba T. Yokota K. Kataoka
spellingShingle	Y. Anraku H. Kuwahara Y. Fukusato A. Mizoguchi T. Ishii K. Nitta Y. Matsumoto K. Toh K. Miyata S. Uchida K. Nishina K. Osada K. Itaka N. Nishiyama H. Mizusawa T. Yamasoba T. Yokota K. Kataoka Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain Nature Communications
author_facet	Y. Anraku H. Kuwahara Y. Fukusato A. Mizoguchi T. Ishii K. Nitta Y. Matsumoto K. Toh K. Miyata S. Uchida K. Nishina K. Osada K. Itaka N. Nishiyama H. Mizusawa T. Yamasoba T. Yokota K. Kataoka
author_sort	Y. Anraku
title	Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
title_short	Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
title_full	Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
title_fullStr	Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
title_full_unstemmed	Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
title_sort	glycaemic control boosts glucosylated nanocarrier crossing the bbb into the brain
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.
url	https://doi.org/10.1038/s41467-017-00952-3
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Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

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