Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus

• Main Authors: Jia Liu, Wenliang Fan, Yuxi Jia, Xiaoyun Su, Wenjun Wu, Xi Long, Xin Sun, Jie Liu, Wengang Sun, Tianjing Zhang, Qiyong Gong, Haojun Shi, Qing Zhu, Jing Wang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-02-01
• Series: Frontiers in Endocrinology
• Subjects: gray matter; type 1 diabetes mellitus; seed-based d mapping; meta-analysis; voxel-based morphometry
• Online Access: https://www.frontiersin.org/article/10.3389/fendo.2020.00045/full

Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted.Materials and Methods: The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics.Results: Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations.Conclusion: This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.