The Plasmodium bottleneck: malaria parasite losses in the mosquito vector

The Plasmodium bottleneck: malaria parasite losses in the mosquito vector

Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and...

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Bibliographic Details
Main Authors: Ryan C Smith, Joel Vega-Rodríguez, Marcelo Jacobs-Lorena
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2014-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
malaria
mosquito
Plasmodium
innate
immunity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500644&lng=en&tlng=en
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spelling doaj-0fb2b0a613d747e990b435ba872b08512020-11-24T22:46:14ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-80602014-08-01109564466110.1590/0074-0276130597S0074-02762014000500644The Plasmodium bottleneck: malaria parasite losses in the mosquito vectorRyan C SmithJoel Vega-RodríguezMarcelo Jacobs-LorenaNearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500644&lng=en&tlng=enmalariamosquitoPlasmodiuminnateimmunity
collection DOAJ
language English
format Article
sources DOAJ
author Ryan C Smith
Joel Vega-Rodríguez
Marcelo Jacobs-Lorena
spellingShingle Ryan C Smith
Joel Vega-Rodríguez
Marcelo Jacobs-Lorena
The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
Memórias do Instituto Oswaldo Cruz.
malaria
mosquito
Plasmodium
innate
immunity
author_facet Ryan C Smith
Joel Vega-Rodríguez
Marcelo Jacobs-Lorena
author_sort Ryan C Smith
title The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
title_short The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
title_full The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
title_fullStr The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
title_full_unstemmed The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
title_sort plasmodium bottleneck: malaria parasite losses in the mosquito vector
publisher Instituto Oswaldo Cruz, Ministério da Saúde
series Memórias do Instituto Oswaldo Cruz.
issn 1678-8060
publishDate 2014-08-01
description Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.
topic malaria
mosquito
Plasmodium
innate
immunity
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500644&lng=en&tlng=en
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AT marcelojacobslorena theplasmodiumbottleneckmalariaparasitelossesinthemosquitovector
AT ryancsmith plasmodiumbottleneckmalariaparasitelossesinthemosquitovector
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