Curcumin Blocks Cytotoxicity of Enteroaggregative and Enteropathogenic Escherichia coli by Blocking Pet and EspC Proteolytic Release From Bacterial Outer Membrane

Curcumin Blocks Cytotoxicity of Enteroaggregative and Enteropathogenic Escherichia coli by Blocking Pet and EspC Proteolytic Release From Bacterial Outer Membrane

Pet and EspC are toxins secreted by enteroaggregative (EAEC) and enteropathogenic (EPEC) diarrheagenic Escherichia coli pathotypes, respectively. Both toxins are members of the Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) family. Pet and EspC are important virulence factors that p...

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Bibliographic Details
Main Authors: Javier I. Sanchez-Villamil, Fernando Navarro-Garcia, Araceli Castillo-Romero, Filiberto Gutierrez-Gutierrez, Daniel Tapia, Gabriela Tapia-Pastrana
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Escherichia coli
pathogenic E. coli
autotransporter
SPATE
beta-barrel
antimicrobial agent
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00334/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00334/full

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