The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression

The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression

Abnormal skin scarring causes functional impairment, psychological stress, and high socioeconomic cost. Evidence shows that altered mechanotransduction pathways have been linked to both inflammation and fibrosis, and that focal adhesion kinase (FAK) is a key mediator of these processes. We investiga...

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Bibliographic Details
Main Authors: Michael Januszyk, Sun Hyung Kwon, Victor W. Wong, Jagannath Padmanabhan, Zeshaan N. Maan, Alexander J. Whittam, Melanie R. Major, Geoffrey C. Gurtner
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
focal adhesion kinase
keratinocyte
mechanotransduction
extracellular matrix
single-cell transcriptional analysis
skin fibrosis
hypertrophic scar
transcriptomics
Online Access:https://www.mdpi.com/1422-0067/18/9/1915

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https://www.mdpi.com/1422-0067/18/9/1915

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