Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4

Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4

Context Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. Objective The interaction between baicalein and simvastatin was investigated to provide reference and guidance for the clinical application of the combinatio...

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Bibliographic Details
Main Authors:	Meng Meng, Xin Li, Xiuwen Zhang, Bin Sun
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Series:	Pharmaceutical Biology
Subjects:	drug-drug interaction scutellariae radix metabolism biotransformation
Online Access:	http://dx.doi.org/10.1080/13880209.2021.1942927

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