Therapeutic Efficacy of <i>Nyctanthes arbor-tristis</i> Flowers to Inhibit Proliferation of Acute and Chronic Primary Human Leukemia Cells, with Adipocyte Differentiation and in Silico Analysis of Interactions between Survivin Protein and Selected Secondary Metabolites

Therapeutic Efficacy of <i>Nyctanthes arbor-tristis</i> Flowers to Inhibit Proliferation of Acute and Chronic Primary Human Leukemia Cells, with Adipocyte Differentiation and in Silico Analysis of Interactions between Survivin Protein and Selected Secondary Metabolites

Although the antidiabetic efficacy of <i>Nyctanthes arbor-tristis</i> flowers has been reported, antiproliferative and anti-obesity activities are yet to be explored. We examined the anti-obesity and antiproliferative potentials of different fractions (hexane, chloroform, ethyl acetate,...

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Main Authors: Saumya Nishanga Heendeniya, Lakshika. Rangi Keerthirathna, Chamalika Kanthini Manawadu, Indeewarie Hemamali Dissanayake, Rizwan Ali, Abdullah Mashhour, Hajar Alzahrani, Pahan Godakumbura, Mohamed Boudjelal, Dinithi Champika Peiris
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
<i>nyctanthes abor-tristis</i>
human breast carcinoma
primary peripheral blood mononuclear cells
acute myeloid leukemia
chronic lymphocytic leukemia
obesity
hypoglycemia
molecular docking
survivin protein
gas chromatography/mass spectrometry
Online Access:https://www.mdpi.com/2218-273X/10/2/165

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