Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging

Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging

In an attempt to develop new tumor imaging radiotracers with favorable biochemical properties, we have synthesized new 68Ga-2-acetylpyridine semicarbazone (68Ga-[APSC]2) as a potential positron emission tomography (PET) tumor imaging agent using a straightforward and a one-step simple reaction. Radi...

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Main Authors: N. S. Al-Hokbany, Basim Alotaibi, Suad Bin Amer, Subhani M. Okarvi, Ibrahim Al-Jammaz
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2014/616459
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spelling doaj-0f8d2a3820384e26b22b88715ca81a3c2020-11-25T00:01:22ZengHindawi LimitedJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/616459616459Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor ImagingN. S. Al-Hokbany0Basim Alotaibi1Suad Bin Amer2Subhani M. Okarvi3Ibrahim Al-Jammaz4Chemistry Department, School of Science, King Saud University, Riyadh, Saudi ArabiaCyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaCyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaCyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaCyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaIn an attempt to develop new tumor imaging radiotracers with favorable biochemical properties, we have synthesized new 68Ga-2-acetylpyridine semicarbazone (68Ga-[APSC]2) as a potential positron emission tomography (PET) tumor imaging agent using a straightforward and a one-step simple reaction. Radiochemical yield and purity were quantitative without HPLC purification. Biodistribution studies in nude mice model bearing human MDA-MB-231 cell line xenografts displayed significant tumor uptake of 68Ga-[APSC]2 radiotracer after 2 h postinjection (p.i.). The initial results demonstrate that 68Ga-[APSC]2 radiotracer may be useful probe for detecting and staging of hypoxic tumor using PET imaging modality.http://dx.doi.org/10.1155/2014/616459
collection DOAJ
language English
format Article
sources DOAJ
author N. S. Al-Hokbany
Basim Alotaibi
Suad Bin Amer
Subhani M. Okarvi
Ibrahim Al-Jammaz
spellingShingle N. S. Al-Hokbany
Basim Alotaibi
Suad Bin Amer
Subhani M. Okarvi
Ibrahim Al-Jammaz
Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
Journal of Chemistry
author_facet N. S. Al-Hokbany
Basim Alotaibi
Suad Bin Amer
Subhani M. Okarvi
Ibrahim Al-Jammaz
author_sort N. S. Al-Hokbany
title Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
title_short Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
title_full Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
title_fullStr Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
title_full_unstemmed Synthesis and In Vitro and In Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
title_sort synthesis and in vitro and in vivo evaluation of a new 68ga-semicarbazone complex: potential pet radiopharmaceutical for tumor imaging
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2014-01-01
description In an attempt to develop new tumor imaging radiotracers with favorable biochemical properties, we have synthesized new 68Ga-2-acetylpyridine semicarbazone (68Ga-[APSC]2) as a potential positron emission tomography (PET) tumor imaging agent using a straightforward and a one-step simple reaction. Radiochemical yield and purity were quantitative without HPLC purification. Biodistribution studies in nude mice model bearing human MDA-MB-231 cell line xenografts displayed significant tumor uptake of 68Ga-[APSC]2 radiotracer after 2 h postinjection (p.i.). The initial results demonstrate that 68Ga-[APSC]2 radiotracer may be useful probe for detecting and staging of hypoxic tumor using PET imaging modality.
url http://dx.doi.org/10.1155/2014/616459
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