B cells are multifunctional players in multiple sclerosis pathogenesis: insights from therapeutic interventions

B cells are multifunctional players in multiple sclerosis pathogenesis: insights from therapeutic interventions

Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS) characterized by autoimmune inflammation and neurodegeneration. Historically, damage to the CNS was thought to be mediated predominantly by activated pro-inflammatory T cells. B cell involvement in the pathogenesis of MS...

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Bibliographic Details
Main Authors: Nele eClaes, Judith eFraussen, Piet eStinissen, Raymond eHupperts, Veerle eSomers
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Immunology
Subjects:
Antibodies
Antigen Presentation
Cytokines
Multiple Sclerosis
therapy
costimulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00642/full

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