Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review

Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review

Background. We present the case of a 35-year-old gentleman who presented with an aggressive cardiomyopathy with normal coronary arteries. He was later diagnosed with systemic lupus-related cardiomyopathy. Methods. We undertook an extensive review of the literature regarding cardiac manifestations of...

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Main Authors: Reza Ashrafi, Pankaj Garg, Ewan McKay, John Gosney, Som Chuah, Gershan Davis
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Cardiology Research and Practice
Online Access:http://dx.doi.org/10.4061/2011/578390
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spelling doaj-0f819ef26bcf45eb9cd862fe04eac0b12020-11-24T23:52:56ZengHindawi LimitedCardiology Research and Practice2090-05972011-01-01201110.4061/2011/578390578390Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature ReviewReza Ashrafi0Pankaj Garg1Ewan McKay2John Gosney3Som Chuah4Gershan Davis5Aintree Cardiac Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UKAintree Cardiac Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UKAintree Cardiac Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UKDepartment of Pathology, The Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UKAintree Cardiac Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UKAintree Cardiac Centre, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UKBackground. We present the case of a 35-year-old gentleman who presented with an aggressive cardiomyopathy with normal coronary arteries. He was later diagnosed with systemic lupus-related cardiomyopathy. Methods. We undertook an extensive review of the literature regarding cardiac manifestations of lupus and used over 100 journals to identify the key points in pathology, diagnosis, and treatment. Results. We have shown that cardiac lupus can be rapidly progressive and, unless treated early, can have severe consequences. The predominant pathologies are immune complex and accelerated atherosclerosis drive. Treatment comprised of high-level immunosuppression.http://dx.doi.org/10.4061/2011/578390
collection DOAJ
language English
format Article
sources DOAJ
author Reza Ashrafi
Pankaj Garg
Ewan McKay
John Gosney
Som Chuah
Gershan Davis
spellingShingle Reza Ashrafi
Pankaj Garg
Ewan McKay
John Gosney
Som Chuah
Gershan Davis
Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review
Cardiology Research and Practice
author_facet Reza Ashrafi
Pankaj Garg
Ewan McKay
John Gosney
Som Chuah
Gershan Davis
author_sort Reza Ashrafi
title Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review
title_short Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review
title_full Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review
title_fullStr Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review
title_full_unstemmed Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review
title_sort aggressive cardiac involvement in systemic lupus erythematosus: a case report and a comprehensive literature review
publisher Hindawi Limited
series Cardiology Research and Practice
issn 2090-0597
publishDate 2011-01-01
description Background. We present the case of a 35-year-old gentleman who presented with an aggressive cardiomyopathy with normal coronary arteries. He was later diagnosed with systemic lupus-related cardiomyopathy. Methods. We undertook an extensive review of the literature regarding cardiac manifestations of lupus and used over 100 journals to identify the key points in pathology, diagnosis, and treatment. Results. We have shown that cardiac lupus can be rapidly progressive and, unless treated early, can have severe consequences. The predominant pathologies are immune complex and accelerated atherosclerosis drive. Treatment comprised of high-level immunosuppression.
url http://dx.doi.org/10.4061/2011/578390
work_keys_str_mv AT rezaashrafi aggressivecardiacinvolvementinsystemiclupuserythematosusacasereportandacomprehensiveliteraturereview
AT pankajgarg aggressivecardiacinvolvementinsystemiclupuserythematosusacasereportandacomprehensiveliteraturereview
AT ewanmckay aggressivecardiacinvolvementinsystemiclupuserythematosusacasereportandacomprehensiveliteraturereview
AT johngosney aggressivecardiacinvolvementinsystemiclupuserythematosusacasereportandacomprehensiveliteraturereview
AT somchuah aggressivecardiacinvolvementinsystemiclupuserythematosusacasereportandacomprehensiveliteraturereview
AT gershandavis aggressivecardiacinvolvementinsystemiclupuserythematosusacasereportandacomprehensiveliteraturereview
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