Valproic Acid-Like Compounds Enhance and Prolong the Radiotherapy Effect on Breast Cancer by Activating and Maintaining Anti-Tumor Immune Function

Valproic Acid-Like Compounds Enhance and Prolong the Radiotherapy Effect on Breast Cancer by Activating and Maintaining Anti-Tumor Immune Function

Inadequate sustained immune activation and tumor recurrence are major limitations of radiotherapy (RT), sustained and targeted activation of the tumor microenvironment can overcome this obstacle. Here, by two models of a primary rat breast cancer and cell co-culture, we demonstrated that valproic ac...

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Bibliographic Details
Main Authors: Zuchao Cai, David Lim, Guochao Liu, Chen Chen, Liya Jin, Wenhua Duan, Chenxia Ding, Qingjie Sun, Junxuan Peng, Chao Dong, Fengmei Zhang, Zhihui Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
VPA-like compounds
radiotherapy
breast cancer
TAMs
M1-like macrophages
CD8+ T
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.646384/full

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