Pharmaceutical Evaluation of Honokiol and Magnolol on Apoptosis and Migration Inhibition in Human Bladder Cancer Cells

Pharmaceutical Evaluation of Honokiol and Magnolol on Apoptosis and Migration Inhibition in Human Bladder Cancer Cells

Among herbal medicines, magnolia bark extract, particularly its components honokiol (Hono) and magnolol (Mag), has been widely documented to have antineoplastic properties. The present study aimed to evaluate the synergism of Hono and Mag in bladder cancer therapy both in vitro and in vivo. Treatmen...

Full description

Bibliographic Details
Main Authors:	Hisao-Hsien Wang, Ying Chen, Chih-Ying Changchien, Hsin-Han Chang, Pei-Jyun Lu, Heidi Mariadas, Yu-Chen Cheng, Sheng-Tang Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Pharmacology
Subjects:	honokiol magnolol apoptosis autophagy bladder cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.549338/full

Similar Items

Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders
by: Jui-Lung Shen, et al.
Published: (2010-09-01)

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties
by: Iris Usach, et al.
Published: (2021-02-01)

Synthesis, Characterization and Biological Evaluation of Magnolol and Honokiol Derivatives with 1,3,5-Triazine of Metformin Cyclization
by: Cui Ren, et al.
Published: (2020-12-01)

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota
by: Fang Chen, et al.
Published: (2021-08-01)

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability
by: Lin HL, et al.
Published: (2021-01-01)

Antifungal Effect of Magnolol and Honokiol from <i>Magnolia officinalis</i> on <i>Alternaria alternata</i> Causing Tobacco Brown Spot
by: Ya-Han Chen, et al.
Published: (2019-06-01)

Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo
by: Sang-Bum Kim, et al.
Published: (2018-06-01)

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells
by: Chung-Ching Chio, et al.
Published: (2018-04-01)

Magnolol Inhibits the Growth of Non-Small Cell Lung Cancer via Inhibiting Microtubule Polymerization
by: Jia Shen, et al.
Published: (2017-07-01)

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
by: Yiping Lin, et al.
Published: (2021-03-01)

Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique, characterization, pharmacokinetics, and evaluation of inhibitory effect on HepG2 cells
by: Wu W, et al.
Published: (2018-09-01)

In vitro inhibitory activities of magnolol against Candida spp.
by: Zhou PR, et al.
Published: (2017-09-01)

Honokiol, a Lignan Biphenol Derived from the Magnolia Tree, Inhibits Dengue Virus Type 2 Infection
by: Chih-Yeu Fang, et al.
Published: (2015-09-01)

Honokiol: A Review of Its Anticancer Potential and Mechanisms
by: Chon Phin Ong, et al.
Published: (2019-12-01)

Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus
by: Xu-Ming Deng, et al.
Published: (2010-03-01)

Semi-Synthesis and In Vitro Anti-Cancer Evaluation of Magnolol Derivatives
by: Xiao-Long Sun, et al.
Published: (2021-07-01)

Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation
by: Xueying Song, et al.
Published: (2021-07-01)

Dental plaque regrowth studies to evaluate chewing gum formulations incorporating magnolia bark extract
by: Gleb N. Komarov, et al.
Published: (2017-10-01)

Magnolol ameliorates the accumulation of reactive oxidative stress and inflammation in diabetic periodontitis
by: Chia-Ming Liu, et al.
Published: (2021-07-01)

Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo
by: Jiann-Hwa Chen, et al.
Published: (2019-12-01)

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
by: Abhishek Manoj Ranaware, et al.
Published: (2018-08-01)

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice
by: Ling Zhao, et al.
Published: (2017-07-01)

CYP3A Excipient-Based Microemulsion Prolongs the Effect of Magnolol on Ischemia Stroke Rats
by: Jiun-Wen Guo, et al.
Published: (2020-08-01)

Induction of Apoptosis, Inhibition of MCL-1, and VEGF-A Expression Are Associated with the Anti-Cancer Efficacy of Magnolol Combined with Regorafenib in Hepatocellular Carcinoma
by: Cheng-Hsien Chen, et al.
Published: (2021-04-01)

Honokiol-loaded polymeric nanoparticles: an active targeting drug delivery system for the treatment of nasopharyngeal carcinoma
by: Bo Yang, et al.
Published: (2017-01-01)

Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol
by: Tse-En Wang, et al.
Published: (2020-08-01)

Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression
by: Youn-Hwan Hwang, et al.
Published: (2018-07-01)

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro
by: Ni-Chun Kuo, et al.
Published: (2020-09-01)

Honokiol, an active compound of Magnolia officinalis, is involved in restoring normal baroreflex sensitivity in hypercholesterolemic rabbits
by: Pei‐Yu Chou, et al.
Published: (2020-02-01)

Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo
by: Tingting Liu, et al.
Published: (2020-11-01)

Honokiol inhibits inflammation and endoplasmic reticulum stress in a rat model of pregnancy-induced hypertension
by: Lihui Wang, et al.
Published: (2020-01-01)

Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo
by: Wang N, et al.
Published: (2017-02-01)

Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells
by: Xi Dai, et al.
Published: (2018-05-01)

Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells
by: Gong-Jhe Wu, et al.
Published: (2020-03-01)

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
by: Chuang Dennis Y, et al.
Published: (2013-01-01)

Honokiol Improves Liver Steatosis in Ovariectomized Mice
by: Yeon-Hui Jeong, et al.
Published: (2018-01-01)

Chemopreventive Activity of Honokiol against 7, 12 - Dimethylbenz[a]anthracene-Induced Mammary Cancer in Female Sprague Dawley Rats
by: Zhenyu Wang, et al.
Published: (2017-05-01)

Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study
by: Yaman Tunc S, et al.
Published: (2016-03-01)

Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice
by: Sun J, et al.
Published: (2015-12-01)

Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188
by: Guoyuan Li, et al.
Published: (2020-01-01)