DNA Methylation Profiles in Whole Blood of Huntington's Disease Patients

DNA Methylation Profiles in Whole Blood of Huntington's Disease Patients

Epigenetic mechanisms, especially DNA methylation, are suggested to play a role in the age-of-onset in Huntington's disease (HD) based on studies on patient brains, and cellular and animal models. Methylation is tissue-specific and it is not clear how HD specific methylation in the brain correl...

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Bibliographic Details
Main Authors: Maja Zadel, Aleš Maver, Anja Kovanda, Borut Peterlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neurology
Subjects:
Huntington's disease
5mC methylation
differential DNA methylation
epigenetics
whole blood
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00655/full

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